Wuheida struck in the Breeders' Cup Filly & Mare Turf at Del Mar for Charlie Appleby and William Buick.
Buick - riding his first Breeders' Cup winner - had his mount handy in third going into the first turn and got a great response from the Godolphin-owned three-year-old in the straight.
In contrast, Frankie Dettori found himself looking for room on the strong-travelling Queen's Trust as Sir Michael Stoute's four-year-old made her bid to repeat last year's success.
She finished with a real rattle but all too late, and it was the Aidan O'Brien-trained Rhododendron who proved the main threat to the winner.
Buick said: "I can't explain it, it means everything to me. I've had plenty of goes and not been successful, so it means everything.
"It's a big team effort - a big thank you to everyone at home."
He added: "Charlie targeted this race for her from a long way out. He is a great trainer and gives me lots of confidence."
Appleby said: "I knew I had the filly in good order, and she has pleased me through the week. Running to the first turn I knew she was in the right position and William gave her a peach of a ride.
"It's great for my team, who have worked so hard, and His Highness (Sheikh Mohammed) for letting me bring her here."