Holywell heads a 15-strong field declared for the Sky Bet Chase at Doncaster on Saturday.
Fourth in last season's Cheltenham Gold Cup, Jonjo O'Neill's nine-year-old has this term struggled to make an impact in either the Charlie Hall Chase at Wetherby or the Betfair Chase at Haydock.
He reverts to handicap company for the first since striking gold at the 2014 Cheltenham Festival but must concede weight all round.
Despite his welter burden of 11st 12lb, Holywell disputes favouritism for a race formerly known as the Great Yorkshire Chase along with the Paul Nicholls-trained Le Mercurey and Alan King's Ziga Boy.
The enigmatic Buywise would not be winning out of turn, having run well in defeat in the Paddy Power Gold Cup and the Caspian Caviar Gold Cup at Cheltenham.
Other contenders include the Venetia Williams-trained veteran Aachen, Charlie Longsdon's Coologue and Dolatulo from Warren Greatrex's yard.