Seventh Heaven is one of three runners for Aidan O'Brien in the Qipco British Champions Fillies & Mares Stakes at Ascot.
The Irish Oaks heroine beat Arc-winning stable companion Found in the Yorkshire Oaks in August and with the stable in scintillating form, she will be well fancied to complete the hat-trick.
O'Brien is also responsible for Ribblesdale Stakes winner Even Song and Park Hill runner-up Pretty Perfect.
Zhukova is unbeaten in three starts this season for Dermot Weld and is another major contender for Ireland.
Last year's runner-up Journey bids to go one better for John Gosden.
It is a measure of the depth of the 13-strong field that the James Fanshawe-trained Speedy Boarding is double-figure odds, despite striking Group One gold on her last two starts in the Prix Jean Romanet and Prix de l'Opera respectively.